压力溃疡在ICU患者中具有很高的患病率，但如果以初始阶段识别，则可预防。在实践中，布拉登规模用于分类高风险患者。本文通过使用MIMIC-III V1.4中可用的数据调查了在电子健康中使用机器学习记录数据的使用。制定了两个主要贡献：评估考虑在住宿期间所有预测的模型的新方法，以及用于机器学习模型的新培训方法。结果与现有技术相比，表现出卓越的性能;此外，所有型号在精密召回曲线中的每个工作点都超过了Braden刻度。 - - les \〜oes por按\〜ao possuem alta preval \ ^ encia em pacientes de Uti e s \〜ao preven \'iveis ao serem endicidificadas em Est \'agios Iniciais。 na pr \'atica materiza-se a escala de braden para classifica \ c {c} \〜ao de pacientes em risco。 Este Artigo Investiga o Uso de Apenizado de M \'Aquina Em Dados de Registros Eletr \ ^ Onicos Para Este Fim，Parir Da Base dados Mimic-III V1.4。 s \〜ao feitas duas contribui \ c {c} \〜oes principais：uma nova abordagem para a avalia \ c {c} \〜ao dos modelos e da escala da escala de braden levando em conta todas作为predi \ c {c} \ 〜oes feitas ao longo das interna \ c {c} \〜oes，euro novo m \'etodo de treinamento para os modelos de aprendizo de m \'aquina。 os结果os overidos superam o estado da arte everifica-se que os modelos superam意义a escala de braden em todos oS pontos de Opera \ c {c} \〜〜ao da curva de precis \〜ao por sensibilidade。

Recently, there has been an interest in improving the resources available in Intrusion Detection System (IDS) techniques. In this sense, several studies related to cybersecurity show that the environment invasions and information kidnapping are increasingly recurrent and complex. The criticality of the business involving operations in an environment using computing resources does not allow the vulnerability of the information. Cybersecurity has taken on a dimension within the universe of indispensable technology in corporations, and the prevention of risks of invasions into the environment is dealt with daily by Security teams. Thus, the main objective of the study was to investigate the Ensemble Learning technique using the Stacking method, supported by the Support Vector Machine (SVM) and k-Nearest Neighbour (kNN) algorithms aiming at an optimization of the results for DDoS attack detection. For this, the Intrusion Detection System concept was used with the application of the Data Mining and Machine Learning Orange tool to obtain better results

Early recognition of clinical deterioration (CD) has vital importance in patients' survival from exacerbation or death. Electronic health records (EHRs) data have been widely employed in Early Warning Scores (EWS) to measure CD risk in hospitalized patients. Recently, EHRs data have been utilized in Machine Learning (ML) models to predict mortality and CD. The ML models have shown superior performance in CD prediction compared to EWS. Since EHRs data are structured and tabular, conventional ML models are generally applied to them, and less effort is put into evaluating the artificial neural network's performance on EHRs data. Thus, in this article, an extremely boosted neural network (XBNet) is used to predict CD, and its performance is compared to eXtreme Gradient Boosting (XGBoost) and random forest (RF) models. For this purpose, 103,105 samples from thirteen Brazilian hospitals are used to generate the models. Moreover, the principal component analysis (PCA) is employed to verify whether it can improve the adopted models' performance. The performance of ML models and Modified Early Warning Score (MEWS), an EWS candidate, are evaluated in CD prediction regarding the accuracy, precision, recall, F1-score, and geometric mean (G-mean) metrics in a 10-fold cross-validation approach. According to the experiments, the XGBoost model obtained the best results in predicting CD among Brazilian hospitals' data.

A new Lossy Causal Temporal Convolutional Neural Network Autoencoder for anomaly detection is proposed in this work. Our framework uses a rate-distortion loss and an entropy bottleneck to learn a compressed latent representation for the task. The main idea of using a rate-distortion loss is to introduce representation flexibility that ignores or becomes robust to unlikely events with distinctive patterns, such as anomalies. These anomalies manifest as unique distortion features that can be accurately detected in testing conditions. This new architecture allows us to train a fully unsupervised model that has high accuracy in detecting anomalies from a distortion score despite being trained with some portion of unlabelled anomalous data. This setting is in stark contrast to many of the state-of-the-art unsupervised methodologies that require the model to be only trained on "normal data". We argue that this partially violates the concept of unsupervised training for anomaly detection as the model uses an informed decision that selects what is normal from abnormal for training. Additionally, there is evidence to suggest it also effects the models ability at generalisation. We demonstrate that models that succeed in the paradigm where they are only trained on normal data fail to be robust when anomalous data is injected into the training. In contrast, our compression-based approach converges to a robust representation that tolerates some anomalous distortion. The robust representation achieved by a model using a rate-distortion loss can be used in a more realistic unsupervised anomaly detection scheme.

ICECUBE是一种用于检测1 GEV和1 PEV之间大气和天体中微子的光学传感器的立方公斤阵列，该阵列已部署1.45 km至2.45 km的南极的冰盖表面以下1.45 km至2.45 km。来自ICE探测器的事件的分类和重建在ICeCube数据分析中起着核心作用。重建和分类事件是一个挑战，这是由于探测器的几何形状，不均匀的散射和冰中光的吸收，并且低于100 GEV的光，每个事件产生的信号光子数量相对较少。为了应对这一挑战，可以将ICECUBE事件表示为点云图形，并将图形神经网络（GNN）作为分类和重建方法。 GNN能够将中微子事件与宇宙射线背景区分开，对不同的中微子事件类型进行分类，并重建沉积的能量，方向和相互作用顶点。基于仿真，我们提供了1-100 GEV能量范围的比较与当前ICECUBE分析中使用的当前最新最大似然技术，包括已知系统不确定性的影响。对于中微子事件分类，与当前的IceCube方法相比，GNN以固定的假阳性速率（FPR）提高了信号效率的18％。另外，GNN在固定信号效率下将FPR的降低超过8（低于半百分比）。对于能源，方向和相互作用顶点的重建，与当前最大似然技术相比，分辨率平均提高了13％-20％。当在GPU上运行时，GNN能够以几乎是2.7 kHz的中位数ICECUBE触发速率的速率处理ICECUBE事件，这打开了在在线搜索瞬态事件中使用低能量中微子的可能性。

强化学习（RL）通过原始像素成像和连续的控制任务在视频游戏中表现出了令人印象深刻的表现。但是，RL的性能较差，例如原始像素图像，例如原始像素图像。人们普遍认为，基于物理状态的RL策略（例如激光传感器测量值）比像素学习相比会产生更有效的样品结果。这项工作提出了一种新方法，该方法从深度地图估算中提取信息，以教授RL代理以执行无人机导航（UAV）的无地图导航。我们提出了深度模仿的对比度无监督的优先表示（DEPTH-CUPRL），该表示具有优先重播记忆的估算图像的深度。我们使用RL和对比度学习的组合，根据图像的RL问题引发。从无人驾驶汽车（UAV）对结果的分析中，可以得出结论，我们的深度cuprl方法在无MAP导航能力中对决策和优于最先进的像素的方法有效。

不平衡的域学习旨在在预测虽然不足的实例中产生准确的模型，但对于该域而言至关重要。该领域的研究主要集中在分类任务上。相比之下，在回归任务的背景下进行的研究数量可以忽略不计。造成这种情况的主要原因之一是缺乏能够专注于最小化极端值误差的损失函数。最近，引入了评估指标：平方错误相关区域（SERA）。该度量标准更加重视在极端值下的错误，同时还考虑了整个目标变量域中的性能，从而防止了严重的偏见。但是，其作为优化度量的有效性尚不清楚。在本文中，我们的目标是研究使用血清作为不平衡回归任务的优化标准的影响。使用梯度增强算法作为概念证明，我们对36个不同域和大小的数据集进行了实验研究。结果表明，使用血清作为目标函数的模型实际上比在极端值的预测中相应的标准增强算法所产生的模型更好。这证实了血清可以作为损失函数嵌入到基于优化的学习算法中，以实现不平衡的回归方案。

通常，基于生物谱系的控制系统可能不依赖于各个预期行为或合作适当运行。相反，这种系统应该了解未经授权的访问尝试的恶意程序。文献中提供的一些作品建议通过步态识别方法来解决问题。这些方法旨在通过内在的可察觉功能来识别人类，尽管穿着衣服或配件。虽然该问题表示相对长时间的挑战，但是为处理问题的大多数技术存在与特征提取和低分类率相关的几个缺点，以及其他问题。然而，最近的深度学习方法是一种强大的一组工具，可以处理几乎任何图像和计算机视觉相关问题，为步态识别提供最重要的结果。因此，这项工作提供了通过步态认可的关于生物识别检测的最近作品的调查汇编，重点是深入学习方法，强调他们的益处，暴露出弱点。此外，它还呈现用于解决相关约束的数据集，方法和体系结构的分类和表征描述。

Accurate determination of a small molecule candidate (ligand) binding pose in its target protein pocket is important for computer-aided drug discovery. Typical rigid-body docking methods ignore the pocket flexibility of protein, while the more accurate pose generation using molecular dynamics is hindered by slow protein dynamics. We develop a tiered tensor transform (3T) algorithm to rapidly generate diverse protein-ligand complex conformations for both pose and affinity estimation in drug screening, requiring neither machine learning training nor lengthy dynamics computation, while maintaining both coarse-grain-like coordinated protein dynamics and atomistic-level details of the complex pocket. The 3T conformation structures we generate are closer to experimental co-crystal structures than those generated by docking software, and more importantly achieve significantly higher accuracy in active ligand classification than traditional ensemble docking using hundreds of experimental protein conformations. 3T structure transformation is decoupled from the system physics, making future usage in other computational scientific domains possible.

Variational autoencoders model high-dimensional data by positing low-dimensional latent variables that are mapped through a flexible distribution parametrized by a neural network. Unfortunately, variational autoencoders often suffer from posterior collapse: the posterior of the latent variables is equal to its prior, rendering the variational autoencoder useless as a means to produce meaningful representations. Existing approaches to posterior collapse often attribute it to the use of neural networks or optimization issues due to variational approximation. In this paper, we consider posterior collapse as a problem of latent variable non-identifiability. We prove that the posterior collapses if and only if the latent variables are non-identifiable in the generative model. This fact implies that posterior collapse is not a phenomenon specific to the use of flexible distributions or approximate inference. Rather, it can occur in classical probabilistic models even with exact inference, which we also demonstrate. Based on these results, we propose a class of latent-identifiable variational autoencoders, deep generative models which enforce identifiability without sacrificing flexibility. This model class resolves the problem of latent variable non-identifiability by leveraging bijective Brenier maps and parameterizing them with input convex neural networks, without special variational inference objectives or optimization tricks. Across synthetic and real datasets, latent-identifiable variational autoencoders outperform existing methods in mitigating posterior collapse and providing meaningful representations of the data.